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The Thr300Ala variant in ATG16L1 is associated with improved survival in...

ObjectiveATG16L1 is an autophagy gene known to control host immune responses to viruses and bacteria. Recently, a non-synonymous single-nucleotide polymorphism in ATG16L1 (Thr300Ala), previously...

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Real friends: Faecalibacterium prausnitzii supports mucosal immune homeostasis

IBD is commonly considered as an exaggerated immune response to the microbiota in a genetically susceptible host. This statement recognises the central role of the enteric microbiota in the...

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Diagnostic accuracy study of anorectal manometry for diagnosis of dyssynergic...

ObjectiveThe diagnostic accuracy of anorectal manometry (AM), which is necessary to diagnose functional defecatory disorders (FDD), is unknown. Using blinded analysis and standardised reporting of...

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Targeting TGR5 in cholangiocyte proliferation: default topic

The transmembrane G protein-coupled receptor TGR5 binds to and is activated by bile acids.12 TGR5 is widely distributed, in animals and humans, in the gallbladder, liver, brown adipose tissue, muscle,...

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Tablet computer-based multimedia enhanced medical training improves...

We read with interest the paper by Ekkelenkamp et al,1 who found that the early use of validated simulators during endoscopy training expedites the learning of procedural skills. Indeed, traditional...

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A novel prepless X-ray imaging capsule for colon cancer screening

MessageThe demand for bowel cleansing hampers participation in screening colonoscopy, while poor preparation impairs adenoma detection. A novel prepless X-ray imaging capsule for colon screening is...

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Correction

Kong KL, Kwong DLW, Chan TH-M, et al. MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor. Gut...

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Next-generation metabolic imaging in pancreatic cancer

In pancreatic ductal adenocarcinoma (PDAC), the lack of specific symptoms or diagnostic markers, the highly aggressive nature of the disease and high intrinsic and acquired therapy resistance all...

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Guts and Love

We need guts in life When we cry first time  Because birth is the first trial of pain We need guts at work When patients seek for health Because medicine may be a victory or a lie We need guts in the...

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Clinical and endoscopic predictors of cytological dysplasia or cancer in a...

ObjectiveThe serrated neoplasia pathway accounts for up to 30% of all sporadic colorectal cancers (CRCs). Sessile serrated adenomas/polyps (SSA/Ps) with cytological dysplasia (SSA/P-D) are a high-risk...

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Serum viral duplex-linear DNA proportion increases with the progression of...

ObjectiveHBV has two forms of genomic DNA, relaxed-circular DNA (rcDNA) and duplex-linear DNA (dlDNA). Compared to rcDNA, dlDNA has been demonstrated to integrate more frequently into host cellular...

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Akkermansia muciniphila and improved metabolic health during a dietary...

ObjectiveIndividuals with obesity and type 2 diabetes differ from lean and healthy individuals in their abundance of certain gut microbial species and microbial gene richness. Abundance of Akkermansia...

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The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic...

Background and aimsGata6 is required to complete and maintain acinar differentiation in the mouse pancreas. Pancreas-specific Gata6 ablation during development causes extensive and persistent...

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Identification of an anti-inflammatory protein from Faecalibacterium...

BackgroundCrohn’s disease (CD)-associated dysbiosis is characterised by a loss of Faecalibacterium prausnitzii, whose culture supernatant exerts an anti-inflammatory effect both in vitro and in vivo....

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Beyond endoscopic mucosal healing in UC: histological remission better...

BackgroundEndoscopic mucosal healing is an established treatment target for UC, yet the value of achieving histological remission remains unclear. AimsTo evaluate histological remission compared to...

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GI highlights from the literature

Basic scienceThe role of interleukin-22 in epithelial barrier integrity Lindemans CA, Calafiore M, Mertelsmann AM, et al. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration....

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Detection of precancerous gastric lesions and gastric cancer through exhaled...

ObjectivesTimely detection of gastric cancer (GC) and the related precancerous lesions could provide a tool for decreasing both cancer mortality and incidence. Design968 breath samples were collected...

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Chimeric antigen receptor (CAR)-engineered T cells redirected against...

ObjectiveThe recent availability of novel antiviral drugs has raised new hope for a more effective treatment of hepatitis C virus (HCV) infection and its severe sequelae. However, in the case of...

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An unusual cause of odynophagia

QuestionA 45-year-old man presented with odynophagia, felt in the region of the upper chest. Upper GI endoscopy was normal and proton pump inhibitor therapy ineffective. Oesophageal function tests...

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MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic...

ObjectivesPancreatic cancer (PCa) is treatable by surgery when detected at an early stage. Non-invasive imaging methods able to detect both established tumours and their precursor lesions are needed to...

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