The Thr300Ala variant in ATG16L1 is associated with improved survival in...
ObjectiveATG16L1 is an autophagy gene known to control host immune responses to viruses and bacteria. Recently, a non-synonymous single-nucleotide polymorphism in ATG16L1 (Thr300Ala), previously...
View ArticleReal friends: Faecalibacterium prausnitzii supports mucosal immune homeostasis
IBD is commonly considered as an exaggerated immune response to the microbiota in a genetically susceptible host. This statement recognises the central role of the enteric microbiota in the...
View ArticleDiagnostic accuracy study of anorectal manometry for diagnosis of dyssynergic...
ObjectiveThe diagnostic accuracy of anorectal manometry (AM), which is necessary to diagnose functional defecatory disorders (FDD), is unknown. Using blinded analysis and standardised reporting of...
View ArticleTargeting TGR5 in cholangiocyte proliferation: default topic
The transmembrane G protein-coupled receptor TGR5 binds to and is activated by bile acids.12 TGR5 is widely distributed, in animals and humans, in the gallbladder, liver, brown adipose tissue, muscle,...
View ArticleTablet computer-based multimedia enhanced medical training improves...
We read with interest the paper by Ekkelenkamp et al,1 who found that the early use of validated simulators during endoscopy training expedites the learning of procedural skills. Indeed, traditional...
View ArticleA novel prepless X-ray imaging capsule for colon cancer screening
MessageThe demand for bowel cleansing hampers participation in screening colonoscopy, while poor preparation impairs adenoma detection. A novel prepless X-ray imaging capsule for colon screening is...
View ArticleCorrection
Kong KL, Kwong DLW, Chan TH-M, et al. MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptor. Gut...
View ArticleNext-generation metabolic imaging in pancreatic cancer
In pancreatic ductal adenocarcinoma (PDAC), the lack of specific symptoms or diagnostic markers, the highly aggressive nature of the disease and high intrinsic and acquired therapy resistance all...
View ArticleGuts and Love
We need guts in life When we cry first time Because birth is the first trial of pain We need guts at work When patients seek for health Because medicine may be a victory or a lie We need guts in the...
View ArticleClinical and endoscopic predictors of cytological dysplasia or cancer in a...
ObjectiveThe serrated neoplasia pathway accounts for up to 30% of all sporadic colorectal cancers (CRCs). Sessile serrated adenomas/polyps (SSA/Ps) with cytological dysplasia (SSA/P-D) are a high-risk...
View ArticleSerum viral duplex-linear DNA proportion increases with the progression of...
ObjectiveHBV has two forms of genomic DNA, relaxed-circular DNA (rcDNA) and duplex-linear DNA (dlDNA). Compared to rcDNA, dlDNA has been demonstrated to integrate more frequently into host cellular...
View ArticleAkkermansia muciniphila and improved metabolic health during a dietary...
ObjectiveIndividuals with obesity and type 2 diabetes differ from lean and healthy individuals in their abundance of certain gut microbial species and microbial gene richness. Abundance of Akkermansia...
View ArticleThe acinar regulator Gata6 suppresses KrasG12V-driven pancreatic...
Background and aimsGata6 is required to complete and maintain acinar differentiation in the mouse pancreas. Pancreas-specific Gata6 ablation during development causes extensive and persistent...
View ArticleIdentification of an anti-inflammatory protein from Faecalibacterium...
BackgroundCrohn’s disease (CD)-associated dysbiosis is characterised by a loss of Faecalibacterium prausnitzii, whose culture supernatant exerts an anti-inflammatory effect both in vitro and in vivo....
View ArticleBeyond endoscopic mucosal healing in UC: histological remission better...
BackgroundEndoscopic mucosal healing is an established treatment target for UC, yet the value of achieving histological remission remains unclear. AimsTo evaluate histological remission compared to...
View ArticleGI highlights from the literature
Basic scienceThe role of interleukin-22 in epithelial barrier integrity Lindemans CA, Calafiore M, Mertelsmann AM, et al. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration....
View ArticleDetection of precancerous gastric lesions and gastric cancer through exhaled...
ObjectivesTimely detection of gastric cancer (GC) and the related precancerous lesions could provide a tool for decreasing both cancer mortality and incidence. Design968 breath samples were collected...
View ArticleChimeric antigen receptor (CAR)-engineered T cells redirected against...
ObjectiveThe recent availability of novel antiviral drugs has raised new hope for a more effective treatment of hepatitis C virus (HCV) infection and its severe sequelae. However, in the case of...
View ArticleAn unusual cause of odynophagia
QuestionA 45-year-old man presented with odynophagia, felt in the region of the upper chest. Upper GI endoscopy was normal and proton pump inhibitor therapy ineffective. Oesophageal function tests...
View ArticleMRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic...
ObjectivesPancreatic cancer (PCa) is treatable by surgery when detected at an early stage. Non-invasive imaging methods able to detect both established tumours and their precursor lesions are needed to...
View ArticleA randomised, double-blind trial comparing budesonide formulations and...
ObjectiveTo investigate the efficacy and safety of two different budesonide formulations (effervescent tablet for orodispersible use (BET) and viscous suspension (BVS)) with different daily dosages for...
View ArticleProton pump inhibitor-responsive oesophageal eosinophilia: an entity...
Consensus diagnostic recommendations to distinguish GORD from eosinophilic oesophagitis (EoE) by response to a trial of proton pump inhibitors (PPIs) unexpectedly uncovered an entity called...
View ArticleEndoscopy in patients on antiplatelet or anticoagulant therapy, including...
The risk of endoscopy in patients on antithrombotics depends on the risks of procedural haemorrhage versus thrombosis due to discontinuation of therapy. P2Y12 receptor antagonists (clopidogrel,...
View ArticleTGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo...
ObjectiveCholestatic liver diseases in humans as well as bile acid (BA)-feeding and common bile duct ligation (CBDL) in rodents trigger hyperplasia of cholangiocytes within the portal fields....
View ArticleAscitic fluid TREM-1 for the diagnosis of spontaneous bacterial peritonitis
We read with interest the study by Knoop et al1 who reported deleterious effects of antibiotics on the intestinal microflora. This observation should motivate the development of powerful tools for the...
View ArticleGut microbiota composition associated with stool consistency
Vandeputte et al1 recently reported a strong effect of stool consistency—as measured by the Bristol Stool Scale (BSS)—on the composition of the gut microbiota in 53 healthy females. This work...
View ArticleLead time bias in estimating survival outcomes
We read with great interest the article by Govindarajan et al,1 whose aim was to compare the survival outcomes among patients with postcolonoscopy colon rectal cancer (PCCRC), patients with...
View ArticlePersistence of endoscopic rectal inflammation in UC treated with infliximab...
Two recent papers by Leal et al1 and by Yarur et al2 focalised their attention on the mechanisms of Tumour Necrosis Factor α (TNF) inhibition by anti-TNFα in patients suffering from IBDs. In...
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